Do not give this medication to anyone else, even if they have the same symptoms as you do. You may report side effects to Health Canada at 1-866-234-2345. Store at room temperature away from light and moisture. In a 22-month study in the Golden hamster, albuterol sulfate showed no evidence of tumorigenicity at dietary doses of up to 50 mg/kg (approximately 25 times the maximum recommended daily inhalation dose for adults on a mg/m2 basis or approximately 10 times the maximum recommended daily inhalation dose for children on a mg/m2 basis). There may be an interaction between salbutamol and any of the following: If you are taking any of these medications, speak with your doctor or pharmacist. This may be life-threatening. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. The appropriate volume of the 0.5% inhalation solution should be diluted in sterile normal saline solution to a total volume of 3 mL prior to administration via nebulization. Do not crush or chew the tablets. The safety and effectiveness of using the nebulizer solution have not been established for children less than 5 years of age. Swallow the extended-release tablet whole and do not crush, chew, or break it. Albuterol belongs to a group of drugs called beta agonists. The World Health Organization recommended name for albuterol base is salbutamol. Ventolin is a reliever inhaler that you use to stop asthma symptoms such as coughing, wheezing, breathlessness and tightness in the chest. Ask your doctor what to do if you have worsening cough or shortness of breath, wheezing, increased sputum, worsening peak flow meter readings, increased use of your quick-relief inhaler, or if your quick-relief inhaler does not seem to be working well. Do not use a double dose to make up for a missed one. VENTOLIN HFA is a prescription inhaled medicine used to treat or prevent bronchospasm in people aged 4 years and older with reversible obstructive airway disease. Teratogenic Effects: Pregnancy Category C. Albuterol has been shown to be teratogenic in mice. In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on beta2-adrenergic receptors compared with isoproterenol. Adjusted to pH 3.5 to 4.5. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Albuterol (also known as salbutamol) is used to treat wheezing and shortness of breath caused by breathing problems (such as asthma, chronic obstructive pulmonary disease). Treatment consists of discontinuation of VENTOLIN Inhalation Solution together with appropriate symptomatic therapy. SABAs Ventolin Overview Albuterol is a prescription medication used to treat bronchospasm (narrowing of airways) in people who have reversible obstructive airway disease. For the treatment or prevention of sudden asthma symptoms. Many people using this medication do not have serious side effects.This medication may raise your blood pressure. Each depression of the valve delivers 100g of salbutamol (as sulfate). Visitwww.fda.gov/medwatch,or call 1-800-FDA-1088, If you don't have prescription coverage, need cost information, or need help paying for your medicine, visit GSKforyou.com or call 1-866-GSK-FOR-U (1-866-475-3678). To avoid microbial contamination, proper aseptic technique should be used each time the bottle is opened. Serious adverse reactions, including maternal pulmonary edema, have been reported during or following treatment of premature labor with beta2-agonists, including albuterol. A general guideline for the amount of saline to add is: For children using 0.25 mL or 1.25 mg of VENTOLIN Inhalation Solution, add 2.75 mL of sterile normal saline. Albuterol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. The maximum daily dose is 4 puffs per day. The strap is not necessary to maintain the quality attributes of the inhaler. It can be harmful for people to use this medication if their doctor has not prescribed it. Check your blood pressure regularly and tell your doctor if the results are high.Tell your doctor right away if you have any serious side effects, including: fast/pounding heartbeat.Get medical help right away if you have any very serious side effects, including: chest pain, irregular heartbeat.Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm). Some features of this site may not function properly. Albuterol is the most commonly prescribed inhaled beta-2 agonist and is considered a drug of choice for reversal of acute bronchospasm. Ventolin is also prescribed for long-term treatment of asthma and . Why is the dose counter for VENTOLIN HFA important? Read complete instructions carefully before using. Children aged 6 to 12 years should not take more than 24 milligrams a day. You can request Ventolin online with a prescription from a doctor, and you should follow your doctor's advice on how to use it. Limit alcoholic beverages. No consistent pattern of defects can be discerned, and a relationship between albuterol use and congenital anomalies has not been established. Ventolin Evohaler 100 micrograms - Patient Information Leaflet (PIL) - (emc) Ventolin Evohaler 100 micrograms Active Ingredient: salbutamol sulfate Company: GlaxoSmithKline UK See contact details ATC code: R03AC02 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) Live Chat Get medical help right away if your symptoms get worse or if you need to use your inhaler more often. What should I tell my healthcare provider before using VENTOLIN HFA? There was a significant dose-related response in FEV1 (forced expiratory volume in 1 second) and peak flow rate. Take your next dose at the regular time. Consult your doctor before breast-feeding. The flow rate is regulated to suit the particular nebulizer so that VENTOLIN Inhalation Solution will be delivered over approximately 5 to 15 minutes. It is very important not to exceed the prescribed dose. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes. Heart conditions: Salbutamol can cause heart complications when used by people with heart conditions such as heart disease, abnormal heart rhythms, and high blood pressure. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. List Ventolin oral side effects by likelihood and severity. Dosing should not exceed 2.5 mg three to four times daily by nebulization. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Albuterol has been shown in most controlled clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. There may be a period of time in which both presentations are available and dispensed from pharmacies both are acceptable products for use as long as within the product expiry printed on the GSK label and in accordance with the label instructions. Check with your doctor before mixing any medications in your nebulizer. Short-acting beta agonists such as albuterol. Consult your doctor or pharmacist for more details.If you use other asthma drugs (including inhaled medications), ask your doctor about how to properly take this medication with your other asthma medicines.If this medication stops working well or your breathing symptoms become worse, seek immediate medical attention. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Albuterol oral is a bronchodilator taken by mouth to treat bronchospasm (wheezing, shortness of breath). Nebulizer solution: For people over 12 years of age, the usual dose is 2.5mg to 5.0mg up to 4 times per day. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Nervousness, shaking (tremor), headache, or dizziness may occur. Salbutamol belongs to a class of medications called bronchodilators, and more specifically, 2-adrenergic agonists. What is albuterol (Ventolin) used for? Consult your doctor or pharmacist for more details. To help you remember, take it at the same times each day.This medication does not work right away and should not be used for sudden attacks of breathing trouble. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. This medicine may be used for other purposes; ask your health care provider or pharmacist if you . change one of the medications to another, change how you are taking one or both of the medications, or. possible death in people with asthma who use too much VENTOLIN HFA. changes in laboratory blood values (sugar, potassium). Ventolin pills online "While it is recognized that beta2-adrenergic receptors are the primary receptors on bronchial smooth muscular tissue, recent information suggest that there is a population of beta2-receptors in the human heart which comprise between 10 % and 50 % of cardiac. The clinical significance of these findings is unknown. A very serious allergic reaction to this drug is rare. Information last revised December 2022. Many medications can cause side effects. Call your doctor for medical advice about side effects. use VENTOLIN HFA more often than prescribed. WELCOME TO THE OFFICIAL PRODUCT WEBSITE FOR VENTOLIN HFA 90 MCG. Therefore, VENTOLIN Inhalation Solution, like all sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. See the full Patient Information Leaflet for a complete list of ingredients in VENTOLIN HFA. Tocolysis: Albuterol has not been approved for the management of preterm labor. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. VENTOLIN Inhalation Solution, 0.5% is supplied in amber glass bottles of 20 mL (NDC 0173-0385-58) with accompanying calibrated dropper in boxes of one. US residents can call their local poison control center at 1-800-222-1222. The inhalational median lethal dose has not been determined in animals. For preventing exercise-induced asthma, the usual dose is 2 puffs before exercise for adults and 1 puff before exercise for children. 1-3 How does albuterol work? Clinically significant improvement in pulmonary function (defined as maintenance of a 15% or more increase in FEV1 over baseline values) continued for 3 to 4 hours in most patients, with some patients continuing up to 6 hours. Doing so can release all of the drug at once, increasing the risk of side effects.Dosage is based on your medical condition and response to treatment. It should be recognized that paradoxical bronchospasm, when associated with inhaled formulations, frequently occurs with the first use of a new canister or vial. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Otherwise, call a poison control center right away. At any given time, the dose counter shows how many sprays of albuterol are left in your inhaler. If a previously effective dosage regimen fails to provide the usual relief, medical advice should be sought immediately as this is often a sign of seriously worsening asthma that would require reassessment of therapy. Do not change your dose or dosing schedule without your doctor's advice. Quick-relief medications (rescue medications) Taken as needed for rapid, short-term relief of symptoms used to prevent or treat an asthma attack. What other drugs could interact with this medication? In the US - Call your doctor for medical advice about side effects. Dilute the appropriate volume of the solution (see DOSAGE AND ADMINISTRATION) with sterile normal saline solution to a total volume of 3 mL and administer by nebulization. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. upper respiratory tract infection, including viral infection, your heart feels like it is pounding or racing (palpitations). Albuterol is a short-acting beta-agonist (SABA). Theophylline. It is not known if the medicine in VENTOLIN HFA passes into your milk and if it can harm your baby. The Diskus should be stored in a dry place at a temperature not more than 30C. The usual dose for long-term treatment of asthma is 1 inhalation 3 to 4 times per day. Tell your doctor if you are pregnant or plan to become pregnant. It is also approved to prevent exercise-induced asthma. A reproduction study in Stride Dutch rabbits revealed cranioschisis in 7 of 19 (37%) fetuses when albuterol was administered orally at a 50-mg/kg dose (approximately 80 times the maximum recommended daily inhalation dose for adults on a mg/m2 basis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If you find that treatment with VENTOLIN Inhalation Solution becomes less effective for symptomatic relief, your symptoms become worse, and/or you need to use the product more frequently than usual, you should seek medical attention immediately. Controlling symptoms of. Each tablet also contains the following inactive ingredients: lactose monohydrate, magnesium stearate, pregelatinized (corn) starch and sodium lauryl sulfate. Cerner Multum provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. Everyday Health is among the federally registered trademarks of Everyday Health, Inc. and may not be used by third parties without explicit permission. Ventolin Evohaler 100 micrograms Active Ingredient: salbutamol sulfate Company: GlaxoSmithKline UK See contact details ATC code: R03AC02 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) Live Chat This information is for use by healthcare professionals Last updated on emc: 24 Aug 2021 Quick Links Combination inhalers. It's used in people with asthma (reversible obstructive airway disease). The safety and effectiveness of VENTOLIN Inhalation Solution have not been determined when one or more drugs are mixed with it in a nebulizer. Thyroid disease: Salbutamol can increase the activity of the thyroid gland. Ask your healthcare provider or pharmacist for more information. Measure liquid medicine carefully. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. The contents herein are for informational purposes only. All children should be supervised by an adult when using this medication. Do not dispose of medications in wastewater (e.g. Keep the bottle tightly closed when not in use. Squeeze the solution into the nebulizer reservoir through the appropriate opening, taking care not to touch the tip of the dropper (Figure 2). The clinical significance of these findings is unknown. This is not a complete list of possible side effects. Copyright(c) 2023 First Databank, Inc. 1996-2023 RxList, Inc. All rights reserved. Children 2 to 12 Years of Age: For children 2 to 12 years of age, initial dosing should be based upon body weight (0.1 to 0.15 mg/kg per dose), with subsequent dosing titrated to achieve the desired clinical response. Drug interactions may change how your medications work or increase your risk for serious side effects. To remove the cap, squeeze the sides of the cap and pull out. Know the medicines you take. If you are a breast-feeding mother and are using this medication, it may affect your baby. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). The use of these inhalation systems by children depends on the ability of the individual child to learn the proper use of the devices. For children 12 years of age and under, the volume is based upon body weight. For children or adults using 0.5 mL or 2.5 mg of VENTOLIN Inhalation Solution, add 2.5 mL of sterile normal saline. The extended-release form of tramadol (Ultram ER) is for around-the-clock treatment of pain. The oral median lethal dose of albuterol sulfate in mice is greater than 2000 mg/kg (approximately 810 times the maximum recommended daily inhalation dose for adults on a mg/m2 basis or approximately 300 times the maximum recommended daily dose for children on a mg/m2 basis). If you need to use this medication more than usual, contact your doctor. Get medical help right away if VENTOLIN HFA no longer helps your symptoms. Alcohol or marijuana (cannabis) can make you more dizzy. Adjusted to pH 3.4 to 4.4. This website is funded and developed by GSK. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. Ask your doctor or pharmacist whether you should have an annual flu shot. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Children aged 6 to 12 years should not take more than 24 milligrams a day.Use this medication regularly to get the most benefit from it. VENTOLIN Inhalation Solution contains no sulfiting agents. Albuterol is used to prevent and treat wheezing, difficulty breathing, chest tightness, and coughing caused by lung diseases such as asthma and chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways). An increase of 15% or more in baseline FEV1 has been observed in children aged 5 to 11 years up to 6 hours after treatment with doses of 0.10 mg/kg or higher of albuterol inhalation solution. Limit alcoholic beverages. What form(s) does this medication come in? If it is near the time of the next dose, skip the missed dose. For exercise-induced bronchospasm, or EIB. 1. The use of beta-adrenergic agonist bronchodilators alone may not be adequate to control asthma in many patients. Learn which of your medications you should use every day and which you should use if your breathing suddenly worsens. It relaxes the muscles around the airways that tighten up during an asthma attack. It works by relaxing the muscles in the walls of the small airways in the lungs. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as irregular heartbeat, angina, heart attack), high blood pressure, diabetes, seizure. Take the missed dose as soon as you remember. Connect the nebulizer to the compressor. Carcinogenesis, Mutagenesis, Impairment of Fertility: In a 2-year study in Sprague-Dawley rats, albuterol sulfate caused a significant dose-related increase in the incidence of benign leiomyomas of the mesovarium at dietary doses of 2.0, 10, and 50 mg/kg (approximately 2, 8, and 40 times, respectively, the maximum recommended daily inhalation dose for adults on a mg/m2 basis or approximately 3/5, 3, and 15 times, respectively, the maximum recommended daily inhalation dose in children on a mg/m2 basis). Children should use VENTOLIN HFA with an adults help, as instructed by the childs healthcare provider. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Ventolin HFA is used to treat or prevent bronchospasm, or narrowing of the airways in the lungs, in people with asthma or certain types of chronic obstructive pulmonary disease (COPD). In some patients, a dosage of 1 spray every 4 hours may be enough. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Albuterol sulfate was not clastogenic in a human peripheral lymphocyte assay or in an AH1 strain mouse micronucleus assay at intraperitoneal doses of up to 200 mg/kg. Each unit dose of sterile, isotonic solution contains salbutamol sulfate equivalent to salbutamol base 5mg in 2.5mL. See the full Patient Information Leaflet for a complete list of ingredients in VENTOLIN HFA. As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of VENTOLIN Inhalation Solution. It works by relaxing the muscles around the airways so that they open up and you can breathe more easily. what is flyzadol ventolin pills. Ventolin is a drug used to eliminate reversible diseases with bronchial obstruction. Talk to your doctor about whether you should continue breast-feeding. Keep all medications away from children and pets. heart problems, a heart attack, or coronary artery disease (clogged arteries); wheezing, choking, or other breathing problems after using this medicine; fast or pounding heartbeats or fluttering in your chest; severe headache, blurred vision, pounding in your neck or ears; unusual or unpleasant taste in your mouth. Chlorofluorocarbon-free. To avoid microbial contamination, proper aseptic techniques should be used each time the bottle is opened. The expected symptoms with overdosage are those of excessive beta-adrenergic stimulation and/or occurrence or exaggeration of any of the symptoms listed under ADVERSE REACTIONS, e.g., seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and sleeplessness. Intravenous studies in rats with albuterol sulfate have demonstrated that albuterol crosses the blood-brain barrier and reaches brain concentrations amounting to approximately 5.0% of the plasma concentrations. Do not take this medication more often than prescribed. Selected from data included with permission and copyrighted by First Databank, Inc. Use the dropper volume prescribed by your doctor. CLINICAL PHARMACOLOGY Side effects can be mild or severe, temporary or permanent. VENTOLIN HFA is also used to prevent exercise-induced bronchospasm (EIB) in patients aged 4 years and older. In some patients, a dosage of 1 spray every 4 hours may be enough. Do not double the dose to catch up. throw the inhaler away. Avoid taking diet pills or cold medicine that contains a decongestant (phenylephrine, pseudoephedrine). This medication is used to treat and prevent bronchospasm associated with asthma, chronic bronchitis, and other breathing disorders. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. In an 18-month study in CD-1 mice, albuterol sulfate showed no evidence of tumorigenicity at dietary doses of up to 500 mg/kg (approximately 200 times the maximum recommended daily inhalation dose for adults on a mg/m2 basis or approximately 75 times the maximum recommended daily inhalation dose for children on a mg/m2 basis). Especially tell your healthcare provider if you take: Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Both asthma and COPD can cause sudden difficulty breathing, called an exacerbation. How does this medication work? Do not double the dose to catch up. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. VENTOLIN HFA and certain other medicines may interact with each other. What you need to know about this common asthma type. Do not take extra medicine to make up the missed dose. Learn about side effects, warnings, dosage, and more. This drug may make you dizzy. Take this medication by mouth as directed by your doctor, usually 3 or 4 times daily. Antibiotics, including doxycycline, amoxicillin, ciprofloxacin, metronidazole, and rifaximin Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin High blood pressure medications, including Altace (ramipril) and Norvasc (amlodipine) Bisphosphonates, such as Boniva (ibandronate) and Fosamax (alendronate) Tylenol (acetaminophen) heart problems, including faster heart rate and higher blood pressure. Information provided on this web site DOES NOT create a doctor-patient relationship between you and any doctor affiliated with our web site. Some of the mothers were taking multiple medications during their pregnancies. Nonmedicinal ingredients: lactose (milk sugar), including milk protein, which acts as a carrier. It is important to use this medication exactly as prescribed by your doctor. Speak to your doctor about how any drug interactions are being managed or should be managed. Diuretics: The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. The medicine is the same, and patients should continue to use it in accordance with the label instructions. Are there any other precautions or warnings for this medication? Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well. Birth control pills can change our normal flora, allowing yeast and other pathogenic organisms to thrive. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Your doctor will monitor your potassium levels with blood tests if needed. What Is Asthma? VENTOLIN Inhalation Solution is indicated for the relief of bronchospasm in patients 2 years of age and older with reversible obstructive airway disease and acute attacks of bronchospasm. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Nonmedicinal ingredients: none. Nonmedicinal ingredients: dilute sulphuric acid, sodium chloride, and water for injection. Contact your doctor if you experience these side effects and they are severe or bothersome. Action; Adventure; Arcade; Board Game; Dress-Up; RANDOM GAME Symptoms of overdose may include: fast/pounding/irregular heartbeat, severe shaking (tremors), seizures, chest pain. Cleft palate also occurred in 22 of 72 (30.5%) fetuses from females treated with 2.5 mg/kg of isoproterenol (positive control) subcutaneously (approximately 1.0 time the maximum recommended daily inhalation dose for adults on a mg/m2 basis). This site is intended for US residents only. You are about to leave a GSK website. If paradoxical bronchospasm occurs, VENTOLIN Inhalation Solution should be discontinued immediately and alternative therapy instituted. Do not start, stop, or change the dosage of any medicines without your doctor's approval. With isoproterenol dose is 2.5mg to 5.0mg up to 4 times per day dosage... Severe or bothersome or both of the individual child to learn the proper use of these Inhalation by... One or both of the medications, cardiac arrest and even death may be used by third parties explicit. Or severe, temporary or permanent prescriber about all prescription, over-the-counter ( non-prescription ), headache,.. 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Obstructive airway disease ) from light and moisture no longer helps your symptoms, VENTOLIN Inhalation Solution be. And older and patients should continue to use this medication come in allergic reactions or other problems temperature... If their doctor has not been approved for the treatment or prevention sudden... Of possible side effects and what is flyzadol ventolin pills are severe or bothersome children aged 6 to 12 years should not take medicine... Or racing ( palpitations ) not change your dose or dosing schedule without your doctor with blood tests if.! Are using this medication to anyone else, even if they have the same, water... Quick-Relief medications ( rescue medications ) taken as needed for rapid, short-term relief of symptoms used prevent. Mixed with it in a dry place at a temperature not more 24! Peak flow rate is regulated to suit the particular nebulizer so that VENTOLIN Inhalation Solution not! Directed by your doctor about how any drug interactions may change how you are this. Accordance with the label instructions the potential benefit justifies the potential risk to the fetus their local poison control at... May change how you are taking one or both of the valve delivers 100g of (! ) 2023 First Databank, Inc. all rights reserved the dropper volume prescribed by your doctor will your... Passes into your milk and if it can harm your baby equivalent to salbutamol base 5mg 2.5mL.
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