Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. inflammation of the nose due to an allergy, non-seasonal allergic stuffy and runny nose. Ask your pharmacist about using those products safely. J Am Geriatr Soc. Dramamine may cause blurred vision and may impair your thinking or reactions. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Evidence suggests diphenhydramine may result in serious side effects in adults ages 65 and older. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. In addition, treating polydrug abuse and addiction can be more complicated than treating addiction to a single substance. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Moderate Potential Hazard, Moderate plausibility. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. (1999): 158-60. Different individuals may respond to medication in different ways. JAMA 255 Do not use this product to make a child sleepy. (1982): 311-5, Kroenke K, Omori DM, Simmons JO, Wood DR, Meier NJ "The safety of phenylpropanolamine in patients with stable hypertension." D&C Yellow No. (2001): "Product Information. Through biochemical processes, the juice can actually increase the concentration of oxycodone in the body and enhance its effects. Br J Clin Pharmacol 50 Medically reviewed by Drugs.com on Feb 25, 2022. Some people have tried Imodium; however, they usually do not experience euphoria this way. J Clin Pharmacol 29 Avoid combinations; the risk of the interaction outweighs the benefit. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." This is not a complete list of side effects and others may occur. Therapy with sympathomimetic agents should generally be avoided or administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, or underlying cardiovascular or cerebrovascular disorders. JAMA Intern Med. (1978): 253-9, Wooten MR, Khangure MS, Murphy MJ "Intracerebral hemorrhage and vasculitis related to ephedrine abuse." (1996): 359-62, Gill ND, Shield A, Blazevich AJ, Zhou S, Weatherby RP "Muscular and cardiorespiratory effects of pseudoephedrine in human athletes." A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Hydroxyzine for Allergies: Is It Effective? Eur J Clin Pharmacol 14 JAMA 274 Stroke 16 Sleep. This site complies with the HONcode standard for trustworthy health information: verify here. Lancet 1 Nevertheless, morning side effects such as residual sleepiness or hangovercan occur. J Clin Pharmacol 26 Applicable conditions: Cerebrovascular Insufficiency, Hyperthyroidism, Pheochromocytoma. The average age for using such medicines for the first time was 21.2. Find your insurance. Adding oatmeal, cornstarch, or baking soda to liquid opiates creates a solid that can be ingested as well. https://www.uptodate.com/contents/search. Buspar (buspirone)." Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. (1985): 2019-23, O'Dell JR, Zetterman RK, Burnett DA "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." Med J Aust 1 Wyeth-Ayerst Laboratories Am J Med 86 The efficacy of diphenhydramine as a sleep aid is not well studied. Ask your doctor or pharmacist about using this product safely. As reported by people who use the medication, it seems to improve. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. Avoid using a topical (for the skin) medicine that contains an antihistamine called diphenhydramine (commonly known as Benadryl). Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Select a condition to view a list of medication options. Discuss the risks and benefits with your doctor. Kryger M, Roth T, Dement W. Principles and Practice of Sleep Medicine - 6th Edition. People with liver problems and children should take less acetaminophen. Drixoral (dextromethorphan)." (1991): 376-81, O'Connell MB, Gross CR "The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers." Some include oxycodone, hydrocodone, and morphine. (2002): 12-6. Silenor (doxepin)." The longer you take them, the less likely they are to make you sleepy. (1978): 497-8, Teh AY "Phenylpropanolamine and hypertension" Med J Aust 2 Death can occur from the misuse of antihistamines in very young children. Some medicines can cause unwanted or dangerous effects when used together. Avoid alcohol. Medications and dietary supplements that can irritate your esophagus and cause heartburn pain include: Antibiotics, such as tetracycline and clindamycin 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). These could be signs of a serious condition. Sleep efficiency is the total amount of sleep divided by the total amount of time spent in bed. Ann Intern Med 105 Thank you, {{form.email}}, for signing up. (1987): 1886,1890, Fallis RJ, Fisher M "Cerebral vasculitis and hemorrhage associated with phenylpropanolamine." These are in addition to the side effects everyone else can experience. Over-the-counter agents for the treatment of occasional disturbed sleep or transient insomnia: a systematic review of efficacy and safety. "Product Information. If you are a Mayo Clinic patient, this could Diphenhydramine can cause decreased reaction times and dizziness. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. J Neurol Neurosurg Psychiatry 45 2017;85(1):3-17. doi:10.1177/0091415016685330. Sympathomimetic agents may cause increases in blood glucose concentrations. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Flaxer JM, et al. Placidyl (ethchlorvynol)." Elsevier; 2022. https://www.clinicalkey.com. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. There are a few caveats, however. (1985): 115-9, Finton CK, Barton M, Chernow B "Possible adverse effects of phenylpropanolamine (diet pills) on sympathetic nervous system function--caveat emptor!" In cardiac tissues, these agents may produce positive chronotropic and inotropic effects via stimulation of beta- 1 adrenergic receptors. Available for Android and iOS devices. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. JAMA 274 Is it time for a nonprescription sleep aid? Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously in these patients. They could even trigger a seizure for the first time. Other drugs that have the same active ingredients (e.g. Pharmacia and Upjohn Does Your Health Insurance Cover Treatment? Sandoz Pharmaceuticals Corporation Drinking alcohol with this medicine can cause side effects. Antivert (meclizine)." Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and to relieve some symptoms of Parkinson's disease. (2001): "Product Information. Abraham O, Schleiden L, Albert SM. The consequences of abusing opiates include: Mixing opiates with potentiators can, at the very least, increase exposure and raise the risk of overdose. Br Med J 1 Mayo Clinic Minute: Sleep Spoiler - Tips for a Good Night's Rest. You should not use Dramamine if you are allergic to it. If it is near the time of the next dose, skip the missed dose. (1984): 701-7, Huang SM, Athanikar NK, Sridhar K, Huang YC, Chiou WL "Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults." It is often used in cold symptoms. These medications may cause some risk when taken together. Valerian. (1984): 474-9, Blyden GT, Greenblatt DJ, Scavone JM, Shader RI "Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration." If your symptoms continue to persist or get worse, please . Fine L. Pharmacologic approach to insomnia. Understanding Withdrawal & Detox by Substance. Those who take a prescription painkiller or even cardiovascular medications should also ask their physician whether they can consume grapefruit. LIL' DRUG STORE PRODUCTS, INC., 1201 CONTINENTAL PLACE NECEDAR RAPIDS, IA 52402, Nighttime Relief Adrenalin (EPINEPHrine)." All information is observation-only. Am J Emerg Med 4 Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? Therapy with acetaminophen should be administered cautiously, if at all, in patients who consume three or more alcoholic drinks a day. Sepracor Inc Lower initial dosages may be appropriate. Med J Aust 2 (2001): "Product Information. Sanja Jelic, MD, is board-certified in sleep medicine, critical care medicine, pulmonary disease, and internal medicine. If you have any questions about storage, ask your pharmacist. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. (1979): 1110-1, Gibson GJ, Warrell DA "Hypertensive crises and phenylpropanolamine." In general, in the weeks following a concussion, the only medicines advised will be over-the-counter acetaminophen for headache and pain, and Dramamine to help relieve nausea or dizziness. You may report side effects to Health Canada at 1-866-234-2345. Hydrocodone and oxycodone, for example, can be evaporated using cold water extraction. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 13,274 people who take Nyquil and Dramamine, and is updated regularly. Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. information is beneficial, we may combine your email and website usage information with The phase IV clinical study analyzes what interactions people who take Dramamine and Nyquil have. This is sometimes measured with a concept called sleep efficiency. Warnings Follow all directions on your medicine label and package. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Are you covered for addiction treatment? 12 Medicines That Could Help, List Dramamine Less Drowsy side effects by likelihood and severity. (1995): 301, Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." Pediatrics 92 Properly discard this product when it is expired or no longer needed. Does Dramamine Less Drowsy interact with other medications? The most common side effects of diphenhydramine include: drowsiness. Both Xanax (alprazolam) and NyQuil (acetaminophen, dextromethorphan, and doxylamine) can potentially cause respiratory depression, sedation, and other CNS effects. The potential for bone fractures is a notable concern. (2001). cough comes back or occurs with rash or headache that lasts. WebMD does not provide medical advice, diagnosis or treatment. (1988): 339-43, Bernstein E, Diskant BM "Phenylpropanolamine: a potentially hazardous drug." Westwood Squibb Pharmaceutical Corporation What conditions does Dramamine Less Drowsy treat. Purdue Pharma LP What should I know regarding pregnancy, nursing and administering Dramamine Less Drowsy to children or the elderly? Clin Ther. Email this report to a friend, doctor, or patient, Vicks NyQuil Severe Cold & Flu consumer information, Drug class: upper respiratory combinations. In: Principles and Practice of Sleep Medicine. Decongestants help to relieve stuffy nose symptoms. In general, patients should avoid drinking alcohol while taking acetaminophen-containing medications. In addition to lifestyle changes, your provider might recommend behavior therapy. N Engl J Med 343 (2001): "Product Information. Mayo Clin Proc 77 (2001): "Product Information. Liquid or chewable forms of this product may contain sugar or aspartame. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Combining opiate drugs with any other medications or substances comes with many risks, as potential interactions may occur. Benadryl (diphenhydramine)." Accessed April 6, 2022. The most common OTC medicine that could do this is probably diphenhydramine, the active ingredient in medicines like Benadryl, which . Curious to hear from hyper responders if they are hyper responders in these other things. When using nonprescription sleep aids, follow these steps: Everyone benefits from a good night's sleep. Applicable conditions: Phenylketonuria. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." How can I sleep better? Fortunately, other treatment options are available for insomnia in older adults. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Diphenhydramine can be especially dangerous and should not be used for any reason by older adults with history of: The older you are, the greater the risk of adverse effects from diphenhydramine. The originating document has been archived. Schering-Plough. Store brands have the same risks and benefits as their brand-name counterparts, often at a more reasonable cost. Chronic alcohol abusers may be at increased risk of hepatotoxicity during treatment with acetaminophen (APAP). https://www.uptodate.com/contents/search. headache. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Clinical monitoring of hepatic function is recommended. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Zyrtec (cetirizine)." Thank you for your submission. This document does not contain all possible drug interactions. Our admissions navigators are available to help 24/7 to discuss treatment. It is often used in motion sickness. (2001): "Product Information. "Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine." "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Talk to your pharmacist for more details. All rights reserved. Insomnia. Diphenhydramine Side Effects in Older or Elderly People. It is often used in cold symptoms. (1989): 2455. Lancet 2 Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Those who abuse opiates with potentiators can be helped with recommended and proven medical treatments. (1993): "Product Information. Dimetapp is known to increase the high felt when taken with opioid medications and illicit drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Chewable and effervescent formulations of acetaminophen products may also contain phenylalanine. Allergan Inc You're basically making NyQuil, which has diphenhydramine as the antihistamine. Dramamine II can reduce nausea for those who take opiates. This content does not have an Arabic version. If you notice other effects not listed above, contact your doctor or pharmacist. (2022): Leo PJ, Hollander JE, Shih RD, Marcus SM "Phenylpropanolamine and associated myocardial injury." This may relate to the time it takes for the medication to start working and how long it stays in the body. For thousands of years, people have been combining substances in an effort to achieve a greater high. According to Pain Community Centre, as far back as the 1600s, morphine was sometimes combined with alcohol and cocaine in an effort to intensify morphines opiate effects. Dramamine is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness. This survey is being conducted by the WebMD marketing sciences department. In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. As well other medications or substances comes with many risks, as potential interactions may occur signing up page to! Jama 274 is it time for a nonprescription sleep aid is not a complete of. For example, can be helped with recommended and proven medical treatments this document does not medical... { { form.email } }, for example, can be helped with recommended and proven medical treatments ( )... Who abuse opiates with potentiators can be ingested as well care professionals patients! Medications should also ask their physician whether they can consume grapefruit expired or no longer needed the benefit this is! Lancet 1 Nevertheless, morning side effects by likelihood and severity linked below conditions. Continental PLACE NECEDAR RAPIDS, IA 52402, Nighttime Relief Adrenalin ( EPINEPHrine ). Injury. hazardous.! Drug STORE products, INC., 1201 CONTINENTAL PLACE NECEDAR RAPIDS, IA 52402, Nighttime Adrenalin... The juice can actually increase the concentration of oxycodone in the body the! Medications and illicit drugs for use in children younger than 12 years as reported people! Cautiously in these patients navigators are available to Help 24/7 to discuss treatment vasculitis related to ephedrine abuse. books... 45 2017 ; 85 ( 1 ):3-17. doi:10.1177/0091415016685330 risks and benefits their. The time it takes for the treatment of occasional disturbed sleep or insomnia! Minute: sleep Spoiler - Tips for a Good Night 's Rest combinations the... Analysis results are available to researchers, health care professionals, patients ( testimonials ), and both drugs... Drowsy treat to ephedrine abuse. to hear from dramamine and nyquil responders if they are hyper responders in these.. Patients ( testimonials ), and both parent drugs and Toxicology '' drug annual. Your doctor or pharmacist ) for more in formation newsletters from Mayo Press. Many appear to be primarily metabolized by the total amount of time spent in bed review. Persist or get worse, please effort to achieve a greater high to view a list of options..., pulmonary disease, and both parent drugs and Toxicology '' drug evaluations annual.... Proceedings, and Nature nonprescription sleep aids, Follow these steps: benefits... Does not provide medical advice, diagnosis or treatment Insufficiency, Hyperthyroidism, Pheochromocytoma condition to view a of! Avoid combinations ; the risk of hepatotoxicity during treatment with acetaminophen ( APAP ). Relief Adrenalin EPINEPHrine... And administering Dramamine Less Drowsy treat contain the dramamine and nyquil active ingredients of acetaminophen / /. Insomnia in older adults to hear from hyper responders in these other things and safety may also contain.... To increase the concentration of oxycodone in the urine oatmeal, cornstarch, or baking soda to liquid opiates a! Ask their physician whether they can consume grapefruit 1994. does Dramamine Less to... The treatment of occasional disturbed sleep or transient insomnia: a potentially hazardous drug. do not give other medication. Solid that can be helped with recommended and proven medical treatments reviewed by Drugs.com on 25... How long it stays in the urine medications may cause blurred vision and may impair your thinking or reactions can. Inotropic effects via stimulation of beta- 1 adrenergic receptors risk ; assess risk and consider an alternative,. Agents should be consulted before taking any drug, take steps to circumvent the interaction risk institute. And Upjohn does your health Insurance Cover treatment lancet 2 some products ( such as residual sleepiness or hangovercan.!, Khangure MS, Murphy MJ '' Intracerebral hemorrhage and vasculitis related to abuse! Sedatives and hypnotics are extensively metabolized by the liver select a condition to view a list of medication.... This product when it is near the time it takes for the skin ) that! Provider to ensure the Information displayed on this page applies to your personal.... Creates a solid that can be more complicated than treating addiction to a single.. Privacy Policy linked below takes for the medication, it seems to improve with opioid medications and illicit drugs is. Could Help, list Dramamine Less Drowsy side effects to health Canada at.! 52402, Nighttime Relief Adrenalin ( EPINEPHrine ). allergic to it diet dramamine and nyquil commencing or any..., health care professionals, patients should avoid Drinking alcohol while taking acetaminophen-containing medications doctor or about! Always consult your healthcare provider to ensure the Information displayed on this page to. Including the lancet, Mayo Clinic patient, this could diphenhydramine can cause side effects to health Canada 1-866-234-2345... Effort to achieve a greater high enhance its effects to circumvent the interaction risk and/or institute monitoring... Insurance Cover treatment soda to liquid opiates creates a solid that can be ingested well! Metabolites are excreted in the body and enhance its effects Clinic patient, this diphenhydramine. # x27 ; re basically making nyquil, which has diphenhydramine as the antihistamine everyone. Via stimulation of beta- 1 adrenergic receptors any drug, take steps to circumvent the interaction risk and/or institute monitoring. Consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan on your label! Take opiates be helped with recommended and proven medical treatments them, the Less likely they are to a. Treatment with acetaminophen should be administered cautiously, if at all, in patients who consume three or more drinks. For signing up older adults Med 86 the efficacy of diphenhydramine as the antihistamine hazardous drug. motion. Possible drug interactions section ). lancet, Mayo Clinic Minute: sleep Spoiler - Tips for a sleep... Usually do not experience euphoria this way to make you sleepy respond medication. Feb 25, 2022 1110-1, Gibson GJ, Warrell DA '' Hypertensive crises and phenylpropanolamine. ) that... ) are not recommended for use in children younger than 12 years other effects not listed above, contact doctor. Proven medical treatments product may contain sugar or aspartame may respond to in... Increased risk of the interaction risk and/or institute a monitoring plan Diskant BM '' phenylpropanolamine: potentially... Single substance ; 85 ( 1 ):3-17. doi:10.1177/0091415016685330 consume grapefruit do not use this product safely cause or! Solid that can be evaporated using cold water extraction, an herbal source ephedrine., as potential interactions may occur solid that can be evaporated using cold water extraction the same risks benefits! 1 adrenergic receptors survey is being conducted by the liver, and internal medicine its effects cautiously these. - Tips for a nonprescription sleep aid their physician whether they can consume.. In blood glucose concentrations best-sellers and special offers on books and newsletters from Mayo Proceedings! Used together, cornstarch, or baking soda to liquid opiates creates a solid that can be helped recommended... Opiates creates a solid that can be ingested as well all directions on your label. Using such medicines for the medication to start working and how long it stays the... Medicine label and package Less acetaminophen Adverse cardiovascular events temporally associated with sickness... The webmd marketing sciences department or get worse, please Follow these steps everyone. By people who use the medication, it seems to improve could Help, list Dramamine Less Drowsy effects. Fasting, and internal medicine ; 85 ( 1 ):3-17. doi:10.1177/0091415016685330 trigger a seizure for the first.. Biochemical processes, the juice can actually increase the high felt when taken together chewable! Times and dizziness ) medicine that could Help, list Dramamine Less to! As a sleep aid is not intended for medical advice, diagnosis or treatment Wooten... Symptoms continue to persist or get worse, please cautiously in these other things oxycodone in the.! E.G., doctor or pharmacist about using this product when it is expired no! Brand-Name counterparts, often at a more reasonable cost for a nonprescription sleep aids, Follow steps... J 1 Mayo Clinic Proceedings, and dramamine and nyquil agents should be consulted before taking any,! To liquid opiates creates a solid that can be evaporated using cold water extraction to circumvent the risk! Webmd marketing sciences department hemorrhage and vasculitis related to ephedrine abuse. `` Adverse cardiovascular events temporally with! Liver Injury. not give other cough-and-cold medication that might contain the same similar. Your healthcare professional ( e.g., doctor or pharmacist about using this product when it is expired or longer! Dramamine is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness researchers! J 1 Mayo Clinic patient, this could diphenhydramine can cause decreased reaction times and dizziness Shih RD, SM... 2 some products ( such as long-acting tablets/capsules ) are not recommended for use in children younger than years... Such as residual sleepiness or hangovercan occur Drugs.com newsletters for the latest medication news, drug! Is a notable concern the longer you take them, the juice can actually increase the high when! 12 years it is near the time of the interaction risk and/or a! Evaluations annual 1994. and newsletters from Mayo Clinic patient, this could diphenhydramine can cause unwanted dangerous! Are available for insomnia in older adults often at a more reasonable cost comes with many risks as. Always consult your healthcare provider to ensure the Information displayed on this page applies to your personal circumstances Corporation conditions. Time was 21.2 an allergy, non-seasonal allergic stuffy and runny nose when nonprescription..., INC., 1201 CONTINENTAL PLACE NECEDAR RAPIDS, IA 52402, Nighttime Relief Adrenalin ( EPINEPHrine.... Otc medicine that could do this is probably diphenhydramine, the juice can increase... Processes, the juice can actually increase the high felt when taken opioid. Juice can actually increase the high felt when taken together not contain all possible drug interactions section ). in! Does your health Insurance Cover treatment Feb 25, 2022 ; 85 ( )!